An innovative, noninvasive treatment option for individuals struggling with Major Depressive Disorder (MDD). 



BrainsWay Deep Transcranial Magnetic Stimulation ( BrainsWay Deep TMS® ). 

This groundbreaking therapy is FDA-cleared and supported by clinical research as a safe and effective solution for Depression.


Why Choose Deep TMS?


Clinically Proven: Backed by extensive peer-reviewed studies.

Safe & Comfortable: No systemic side effects or sedation required.

Quick Sessions: Each session lasts around 20 minutes.

No Downtime: Patients can resume daily activities immediately.


BrainsWay Deep TMS™: Superior Science

BrainsWay Deep TMS® treatment stimulates areas of the brain associated with depression using the H1 and H7 coils, which target regions responsible for motivation, reward, and pleasure.


Why BrainsWay is Different


BrainsWay’s unique coil design enables deeper and broader brain stimulation compared to traditional figure-8 TMS coils.

This leads to greater neuron activation and less chance of targeting errors, making it a more precise and effective treatment option.


How Deep TMS Works – A 3D Experience

BrainsWay Deep TMS®  uses patented H-coil technology to deliver precise magnetic pulses to areas of the brain that play a key role in mood and emotional regulation.


You'll see a transparent head model with the H-coil gently placed on the scalp.


Magnetic pulses travel through the skull, reaching the dorsolateral prefrontal cortex (DLPFC)—the area most impacted by depression.




These fields stimulate neural activity, helping to regulate mood and behavior.

Neural pathways begin to illuminate, symbolizing the therapeutic activation of mood-related circuits.



These deeper and broader pulses stimulate brain areas more effectively than traditional TMS, promoting emotional balance and symptom relief.







Deep TMS for Major Depressive Disorder


1. Dorsolateral Prefrontal Cortex (DLPFC) → Subgenual Cingulate (BA25)

What happens: Stimulation of the left DLPFC increases top-down regulatory control over the subgenual anterior cingulate cortex (sgACC).

Why it matters: In depression, the sgACC is often hyperactive, associated with persistent negative mood and rumination. Deep TMS helps reduce this overactivity.

2. DLPFC → Ventromedial Prefrontal Cortex (vmPFC)

Effect: Restores balance between emotion regulation and emotional reactivity.

Outcome: Improves resilience to stress, better mood regulation, and decreases in anxiety-like symptoms.

3. DLPFC ↔ Striatum (Nucleus Accumbens)

Pathway involved in: Reward processing and motivation.

Deep TMS effect: Increases dopamine signaling and connectivity in this loop, leading to improved pleasure, motivation, and drive, key deficits in major depression.

4. DLPFC → Amygdala

Role: The DLPFC exerts inhibitory control over the amygdala, which processes fear and negative emotional stimuli.

Deep TMS effect: Decreases amygdala hyperactivity, helping reduce emotional overreactivity and anxiety.

5. DLPFC → Hippocampus

Function: Memory, contextual emotion processing, and HPA axis regulation.

Benefit: Enhancing DLPFC-hippocampal pathways contributes to cognitive clarity, memory improvements, and emotional grounding.

Functional Effects Observed


Supporting Evidence

Levkovitz et al., World Psychiatry (2015) – showed increased connectivity between DLPFC and subcortical emotion circuits post-TMS.Zangen et al., 

Brain Stimulation (2020) – Real-world outcomes show ~82% response and ~65% remission in treatment-resistant depression.

Fox et al., PNAS (2012) – Mapped key networks modulated by DLPFC stimulation, emphasizing its central hub role.

Understanding Depression (MDD) and Anxious Depression


Major Depressive Disorder (MDD) is a serious and often disabling mental health condition. 


According to the American Psychiatric Association, it affects various aspects of life, 
from emotional wellbeing to daily functioning.


People experiencing depression may feel:

Deep sadness and emptiness

Lack of interest in activities they once enjoyed

Hopelessness and low energy

Difficulty concentrating or making decisions


Prevalence:

Around 7% of U.S. adults (17+ million people) experience 

at least one major depressive episode annually.


Risk Factors:

Family history of depression

Traumatic or stressful life events

Chronic medical conditions

Hormonal or neurochemical imbalances


Clinical Evidence


This means that 6 out of 10 patients experienced a complete absence of Depressive symptoms after treatment—a remarkable achievement for individuals with Treatment-Resistant Depression. 


This disparity underscores the importance of using multiple assessment tools. Regardless, the data overwhelmingly demonstrates that BrainsWay Deep TMS can offer meaningful recovery, not just symptomatic relief, for those suffering from major depressive disorder.








This chart summarizes the clinical success of Transcranial Magnetic Stimulation (TMS) therapy at the TMS Serenity Center, based on a real-world, retrospective study involving 123 patients diagnosed with unipolar, non-psychotic Major Depressive Disorder.



According to the data, an impressive 76.4% of patients achieved a “response”—defined as a ≥50% reduction in depression scores from baseline.

 

This high response rate reflects a significant improvement in mood, motivation, and daily functioning for the majority of participants. It suggests that Deep TMS therapy remains highly effective even outside controlled clinical trial settings.


Even more notably, 72.4% of patients reached full “remission”, meaning their final depression scores fell to 13 or below on standardized scales—a threshold often used to define minimal or no clinical depression. 


The average depression score dropped from 25.6 at baseline to just 10.2, reinforcing the sustained, measurable benefits of TMS. 

These findings, presented at the American Psychiatric Association (APA) Annual Meeting, underscore Deep TMS as a robust, non-invasive treatment option with both rapid and lasting results for patients who may not have responded to medication alone.

How BrainsWay Deep TMSĀ® Treatment Works Over Time


BrainsWay Deep TMS®  treatment is done in two main phases to help you feel better and stay well.


Phase 1 – Acute Phase (Weeks 1–4): You’ll come in for treatment 5 days a week for about 20 minutes each session. 

This adds up to 20 treatments in total. During the session, you’ll be fully awake and relaxed—no medication or anesthesia needed. This first phase helps your brain start healing quickly, especially in areas that control mood and energy.

Phase 2 – Continuation Phase (Weeks 6–11): After the first month, you’ll switch to 2 sessions a week. 

This helps keep the progress going and lowers the chance of depression coming back. Some people may also do occasional maintenance sessions depending on how they’re feeling.

This treatment plan is designed to help you feel better and stay better over time.